Feeling Tired, Weak, and Foggy After 40? Why Creatine Might Be the Missing Piece in Your Health Toolkit

Feeling Tired, Weak, and Foggy After 40? Why Creatine Might Be the Missing Piece in Your Health Toolkit

August 10, 20259 min read

The supplement that could help restore your energy, strength, and mental clarity during midlife and beyond

Picture this: You walk into a supplement store and ask about creatine. The 22-year-old behind the counter immediately assumes you're shopping for your boyfriend and starts explaining how it'll help him "get swole."

Sound familiar?

I've been there too, and honestly, it's infuriating. Because here's what that young man doesn't know: creatine might actually be MORE beneficial for women than men – especially those of us navigating the wild ride of midlife hormones.

So let's set the record straight once and for all.

What Exactly IS Creatine? (And No, It's Not a Steroid)

Before we dive into why you should care about creatine, let's clear up the biggest misconception: creatine is NOT a steroid.

Creatine is actually an amino acid derivative that your body naturally produces. Think of it as your muscles' personal energy drink – it helps create ATP (adenosine triphosphate), which is basically the currency your cells use for quick, powerful movements.

In simpler terms? Creatine helps your muscles work harder for longer. Whether you're lifting weights, chasing grandkids, or just trying to get through your day with more energy, creatine gives your muscles the fuel they need to perform.

Why Women Need to Pay Attention (Spoiler: We're Starting at a Disadvantage)

Here's where things get interesting – and a little frustrating.

Research shows that women naturally have 70-80% fewer creatine stores than men. We also typically eat less dietary creatine because we consume less red meat (beef, lamb, pork) and fish than our male counterparts.

So essentially, we're starting this whole "having energy and strength" game with a significant handicap. No wonder we feel tired all the time!

This is where supplementation comes in. When we take creatine monohydrate (the gold standard form), we're essentially leveling the playing field and giving our bodies the fuel they've been missing.

The Real Benefits: Beyond Just "Getting Stronger"

1. Improved Strength and Performance

Yes, creatine can help you lift heavier weights and do more reps. But let's think bigger picture: stronger muscles mean better functional movement, less risk of falls, and the ability to maintain independence as we age. That's not about vanity – that's about quality of life.

2. Better Bone and Cardiovascular Health

Here's something the gym bros don't talk about: creatine supports bone health and cardiovascular function, particularly in older adults. How? By enabling you to do more exercise consistently. When you can lift heavier and recover faster, you're more likely to stick with your workout routine – and that consistency is what really moves the needle on long-term health.

3. Brain Health and Cognitive Function

This is where creatine gets really exciting for us. Your brain uses a LOT of energy, and creatine helps supply it. Studies show that creatine supplementation can improve cognitive processing, especially when you're dealing with:

  • Sleep deprivation (hello, 3 AM wake-ups!)

  • Acute stress

  • Age-related cognitive changes

  • Depression and mood disorders

Think of creatine as premium fuel for your brain during those moments when you feel like you're thinking through molasses.

But Is It Actually Safe? (Addressing the Elephant in the Room)

I get it – you've probably heard scary stories about creatine. Let me put your mind at ease with some facts:

The kidney concern: This is the big one everyone worries about. Here's the truth: creatine supplementation can increase blood creatinine levels (a marker doctors use to check kidney function), but this doesn't mean creatine is harming your kidneys. It's simply a byproduct of creatine breakdown. The research consistently shows that creatine is not harmful to healthy kidneys.

Water retention: Some people experience mild water retention with creatine, which can potentially affect blood pressure medications. Interestingly, men seem to experience this more than women.

The bottom line: Decades of research support creatine's safety profile. It's one of the most studied supplements in the world. However, like with any supplement, you should discuss it with your healthcare provider, especially if you're taking medications or have existing health conditions.

What About Pregnancy and Breastfeeding?

The honest answer? We don't have extensive research on creatine use during pregnancy and breastfeeding in humans. The limited studies we do have suggest it might be safe and potentially beneficial, but this is definitely a conversation to have with your healthcare provider.

When in doubt, err on the side of caution and wait until after you're done breastfeeding to start supplementation.

How to Actually Take Creatine (It's Simpler Than You Think)

Forget everything you've heard about "loading phases" and complicated timing protocols. Here's what the research actually supports:

Dosage: 3-5 grams per day of creatine monohydrate

Timing: Doesn't matter much – take it whenever you remember

Consistency: This is key – take it every day, not just on workout days

Patience: Give it at least 2 months before evaluating results

You can mix it with water, coffee, your morning smoothie – whatever works for you. It's virtually tasteless and dissolves easily.

Ready to try high-quality creatine? I've carefully selected trusted brands that I recommend to my clients. You can find them in my online dispensary under "Protein & Muscle Support" or "Brain Support" categories: Shop Quality Creatine Here

Plus, my community members get 15% off all supplements!

The Real Talk: What to Expect (And What Not to Expect)

Let's manage expectations here. Creatine isn't going to transform you overnight into Wonder Woman. What you might notice over time:

  • Ability to do a few more reps during strength training

  • Faster recovery between sets

  • Less fatigue during high-intensity activities

  • Improved mental clarity, especially during stressful periods

  • Better overall exercise tolerance

What you WON'T experience:

  • Sudden, dramatic muscle gain

  • Immediate strength increases

  • Magic energy boosts (this isn't caffeine)

  • Any "steroid-like" effects (because it's not a steroid!)

Should YOU Try Creatine?

Creatine might be a good fit for you if:

  • You're doing regular strength training or high-intensity exercise

  • You want to support your long-term bone and muscle health

  • You're dealing with brain fog or cognitive fatigue

  • You're looking for evidence-based ways to support healthy aging

It might NOT be right for you if:

  • You have kidney disease (discuss with your doctor)

  • You're pregnant or breastfeeding (again, discuss with your doctor)

  • You're taking medications that could interact with supplements

The Bottom Line

For too long, creatine has been marketed as a "men's supplement" designed to help young guys bulk up. But the science tells a different story – one where women, particularly those of us in midlife, might actually benefit more from creatine supplementation than anyone else.

We're fighting against naturally lower creatine stores, hormonal changes that affect our energy and strength, and age-related declines in muscle mass and cognitive function. Creatine won't solve all these challenges, but it can be a valuable tool in our toolkit.

As with any supplement, the key is being informed and working with healthcare providers who understand your unique situation. Don't let outdated stereotypes keep you from exploring options that could genuinely improve your quality of life.

Remember: taking care of your body isn't vanity – it's maintenance. And sometimes, that maintenance includes giving your muscles and brain the fuel they need to function at their best.

Ready to try high-quality creatine? I've carefully selected trusted brands that I recommend to my clients. You can find them in my online dispensary under "Protein & Muscle Support" or "Brain Support" categories: Shop Quality Creatine Here

Plus, my community members get 15% off all supplements!

Always consult with your healthcare provider before starting any new supplement regimen, especially if you have existing health conditions or take medications.


Supporting Research

  1. Brosnan JT, Brosnan ME. Creatine: endogenous metabolite, dietary, and therapeutic supplement. Annu Rev Nutr. 2007;27:241–61.

  2. Smith-Ryan AE, Cabre HE, Eckerson JM, Candow DG. Creatine Supplementation in Women's Health: A Lifespan Perspective. Nutrients [Internet]. 2021 Mar 8;13(3). Available from: http://dx.doi.org/10.3390/nu13030877

  3. Forbes SC, Candow DG, Ostojic SM, Roberts MD, Chilibeck PD. Meta-Analysis Examining the Importance of Creatine Ingestion Strategies on Lean Tissue Mass and Strength in Older Adults. Nutrients [Internet]. 2021 Jun 2;13(6). Available from: http://dx.doi.org/10.3390/nu13061912

  4. Sims ST, Kerksick CM, Smith-Ryan AE, Janse de Jonge XAK, Hirsch KR, Arent SM, et al. International society of sports nutrition position stand: nutritional concerns of the female athlete. J Int Soc Sports Nutr. 2023 Dec;20(1):2204066.

  5. Candow DG, Forbes SC, Ostojic SM, Prokopidis K, Stock MS, Harmon KK, et al. "Heads Up" for Creatine Supplementation and its Potential Applications for Brain Health and Function. Sports Med. 2023 Dec;53(Suppl 1):49–65.

  6. Vandenberghe K, Goris M, Van Hecke P, Van Leemputte M, Vangerven L, Hespel P. Longterm creatine intake is beneficial to muscle performance during resistance training. J Appl Physiol. 1997 Dec;83(6):2055–63.

  7. Brenner M, Walberg Rankin J, Sebolt D. The effect of creatine supplementation during resistance training in women. J Strength Cond Res. 2000;14(2):207.

  8. Larson-Meyer DE, Hunter GR, Trowbridge CA, Turk JC, Ernest JM, Torman SL, et al. The effect of creatine supplementation on muscle strength and body composition during offseason training in female soccer players. J Strength Cond Res. 2000 Nov;14(4):434–42.

  9. Forbes SC, Candow DG, Ferreira LHB, Souza-Junior TP. Effects of creatine supplementation on properties of muscle, bone, and brain function in older adults: A narrative review. J Diet Suppl. 2022;19(3):318–35.

  10. Wyss M, Schulze A. Health implications of creatine: can oral creatine supplementation protect against neurological and atherosclerotic disease? Neuroscience. 2002;112(2):243–60.

  11. Roschel H, Gualano B, Ostojic SM, Rawson ES. Creatine supplementation and brain health. Nutrients [Internet]. 2021 Feb 10;13(2). Available from: http://dx.doi.org/10.3390/nu13020586

  12. Forbes SC, Cordingley DM, Cornish SM, Gualano B, Roschel H, Ostojic SM, et al. Effects of creatine supplementation on brain function and health. Nutrients [Internet]. 2022 Feb 22;14(5). Available from: http://dx.doi.org/10.3390/nu14050921

  13. Williamson L, New D. How the use of creatine supplements can elevate serum creatinine in the absence of underlying kidney pathology. BMJ Case Rep [Internet]. 2014 Sep 19;2014. Available from: http://dx.doi.org/10.1136/bcr-2014-204754

  14. Antonio J, Candow DG, Forbes SC, Gualano B, Jagim AR, Kreider RB, et al. Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show? J Int Soc Sports Nutr. 2021 Feb 8;18(1):13.

  15. Longobardi I, Gualano B, Seguro AC, Roschel H. Is it time for a requiem for creatine supplementation-induced kidney failure? A narrative review. Nutrients [Internet]. 2023 Mar 18;15(6). Available from: https://pubmed.ncbi.nlm.nih.gov/36986197/

  16. Kreider RB, Kalman DS, Antonio J, Ziegenfuss TN, Wildman R, Collins R, et al. International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. J Int Soc Sports Nutr. 2017 Jun 13;14:18.

  17. Gualano B, Roschel H, Lancha-Jr AH, Brightbill CE, Rawson ES. In sickness and in health: the widespread application of creatine supplementation. Amino Acids. 2012 Aug;43(2):519–29.

Certified Nutritionist & Menopause Specialist

Leah Vachani

Certified Nutritionist & Menopause Specialist

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